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Chromosome copy number changes in Mps1DK-driven p53 null T-ALL samples

ABSTRACT: Mps1DK and p53 loss were combined in T-cells specificely leading to early onset and highly aggressive aneuploid T-ALL. Tumors were characterized for (recurrrent) copy number changes with a focus on whole chromosome abnormalities. DNA content was compared to the DNA content of sex-matched uninfiltrated control liver samples from litter mates

ORGANISM(S): Mus musculus

PROVIDER: GSE57331 | GEO | 2014/07/01

SECONDARY ACCESSION(S): PRJNA246284

REPOSITORIES: GEO

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Chromosome copy number changes in Mps1DK-driven p53 null T-ALL samples

Project description:Mps1DK and p53 loss were combined in T-cells specificely leading to early onset and highly aggressive aneuploid T-ALL. Tumors were characterized for (recurrrent) copy number changes with a focus on whole chromosome abnormalities. DNA content was compared to the DNA content of sex-matched uninfiltrated control liver samples from litter mates 27 Mps1DK p53f/f of Mps1DK p53f/+ tumors and 5 p53 f/f control tumors

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