Transcriptomics

Dataset Information

0

Identification of targets regulated by SELP in HSC


ABSTRACT: To understand the underlying mechanism by which Alox15 gene is required by HSCs, we performed a comparative DNA microarray analysis using total RNA isolated from wild type Lin-Sca-1+c-Kit+, SELP-/- Lin-Sca-1+c-Kit+. The result was validated by quantitative real-time PCR analysis of wild type Lin-Sca-1+c-Kit+ and SELP-/- Lin-Sca-1+c-Kit+. Cancer stem cells are responsible for the initiation and maintenance of some types of cancer, and few effective target genes in these stem cells have been identified. Here we show that the selp is essential for the survival of leukemia stem cells (LSCs) in BCR-ABL-induced chronic myeloid leukemia (CML). To understand the underlying mechanism through which SELP regulates the function of HSCs, the gene expression profiles between WT and Selp-/- HSCs were compared.

ORGANISM(S): Mus musculus

PROVIDER: GSE57459 | GEO | 2014/05/09

SECONDARY ACCESSION(S): PRJNA246487

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-05-09 | E-GEOD-57459 | biostudies-arrayexpress
2011-05-17 | E-GEOD-29348 | biostudies-arrayexpress
2011-05-17 | GSE29348 | GEO
2012-04-04 | GSE35110 | GEO
2012-04-03 | E-GEOD-35110 | biostudies-arrayexpress
2010-01-01 | GSE18446 | GEO
2013-06-25 | GSE40284 | GEO
2023-12-19 | GSE242036 | GEO
2023-10-16 | E-MTAB-12310 | biostudies-arrayexpress
2012-07-06 | GSE36096 | GEO