Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression analysis of pre-metastatic lungs

ABSTRACT: The immune system sustains inflammation, and can occasionally inhibit tumor development. Conversely, chronic inflammation positively contributes to the development of cancer. Furthermore, it was revealed that the large number of macrophages and haematopoietic progenitor cells accumulate in response to primary tumors in pre-metastatic lungs. However, the relationship between the inflammation-like state induced by primary tumors in pre-metastatic phase and the migration of tumor cells in metastasis is not well understood. Here we analyzed transcriptional change of the lungs by pre-metastatic stimuli. Keywords: Gene expression analysis of pre-metastatic lungs

ORGANISM(S): Mus musculus

PROVIDER: GSE5778 | GEO | 2008/12/06

SECONDARY ACCESSION(S): PRJNA97129

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcription profiling of mouse pre-metastatic lungs

Project description:The immune system sustains inflammation, and can occasionally inhibit tumor development. Conversely, chronic inflammation positively contributes to the development of cancer. Furthermore, it was revealed that the large number of macrophages and haematopoietic progenitor cells accumulate in response to primary tumors in pre-metastatic lungs. However, the relationship between the inflammation-like state induced by primary tumors in pre-metastatic phase and the migration of tumor cells in metastasis is not well understood. Here we analyzed transcriptional change of the lungs by pre-metastatic stimuli. Experiment Overall Design: We examined the lungs derived from mice that had been injected with tumor cells into the back subcutaneously. This model mimics pre-metastatic lungs responding to a primary tumor before tumor cells reach the lungs.

2009-01-13 | E-GEOD-5778 | biostudies-arrayexpress

CircRNAs expression profile in Mus musculus pre-metastatic lungs

Project description:CircRNAs expression profile in Mus musculus pre-metastatic lungs

| PRJNA1147594 | ENA

Detecting metastatic tumors after γ-irradiation using longitudinal molecular imaging and gene expression profiling of metastatic tumor nodules

Project description:Microarray analysis in the mouse metastatic tumor after ɣ-irradiation(ɣ-IR): non-irradiated primary tumor vs. radiated primary tumor vs. metastatic tumor after ɣ-irradiation Metastatic tumors in C6-L (rat glioma cells ) xenografted mice were studied after local treatment with fractionated γ-IR. To accurately detect the metastatic nodules after γ-IR, we observed the effect of γ-IR on distant metastatic tumor growth. Metastatic nodules after γ-IR indicated extensive colonization of C6-L cells in the lungs within 6 weeks after γ-IR. Identified and described the molecular events occurring after γ-IR through gene expression profiling to elucidate genetic changes (differentially expressed genes between the γ-IR primary tumors vs. non-γ-IR primary tumors and metastatic lung nodules vs. γ-IR primary tumors). We investigated the change of gene expression profile in the γ-IR primary tumors vs. non-γ-IR primary tumors and metastatic lung nodules vs. γ-IR primary tumors in rat glioma (C6-L cell) xenograft model.

2015-09-18 | E-GEOD-73116 | biostudies-arrayexpress

Expression data on freshly isolated lungs from Atf4wt/wt and Atf4D/D mice.

Project description:Since acute deletion of host ATF4 caused a significant tumor-inhibitory phenotype, and since activated CAFs also play a critical role in the establishment of the metastatic niche we speculated that ATF4 deficiency could also result in an inhibitory effect on lung metastasis. Thus, we examined the impact of host ATF4 deletion in the pre-metastatic niche by analyzing gene expression changes on lungs from Atf4wt/wt and Atf4D/D mice at 4 weeks post tamoxifen treatment. Genome-wide microarray analysis identified 21 genes to be significantly downregulated in Atf4D/D lungs, including collagen-associated genes. Also, pathway analysis on the most dysregulated genes revealed defects on collagen formation, extracellular matrix organization and integrin cell surface interactions pathways.

2022-05-25 | GSE159012 | GEO

Detecting metastatic tumors after γ-irradiation using longitudinal molecular imaging and gene expression profiling of metastatic tumor nodules

2015-09-18 | GSE73116 | GEO

Mus musculus

Project description:Gene expression analysis of pre-metastatic lungs

| PRJNA97129 | ENA

Expression and MeDIP microarray data from IL13-induced allergic airway inflammation of mice lungs

Project description:This SuperSeries is composed of the following subset Series: GSE35979: Gene expression data from IL13-induced allergic airway inflammation of mice lungs GSE35980: MicroRNA expression data from IL13-induced allergic airway inflammation of mice lungs GSE37079: Methylated DNA immunoprecipitation (MeDIP) microarray data from IL13-induced allergic airway inflammation of mouse lungs Refer to individual Series

2012-04-06 | E-GEOD-37085 | biostudies-arrayexpress

Protein expression profiling of serum and lungs at different stages of metastatic development in a human triple negative breast cancer xenograft model - Part 1

Project description:The main objective of this study was to evaluate the protein expression profiling of serum and lungs at different stages of metastatic development in a human triple negative MDA-MB

2019-05-07 | PXD010248 | Pride

SERUM_Protein expression profiling of serum and lungs at different stages of metastatic development in a human triple negative breast cancer xenograft model - Part 2

2019-05-07 | PXD010249 | Pride

A preliminary study on the clinicopathological characterization of gingival metastatic tumors and their mechanism of occurrence

Project description:Metastatic tumors of the gingiva are very rare tumors that are easily overlooked due to the lack of specific signs and symptoms, and pose a challenge to clinicians. Their common primary sites include the lungs, liver, stomach, and kidneys, and they usually occur in the advanced stages of the tumor, and the interval between presentation and death is usually short; therefore, patients with gingival lesions, especially those with a history of malignancy, need to be carefully and accurately diagnosed. Some tumors tend to have insignificant symptoms in the primary focus and secondary gingival swelling as their first symptom. It is often difficult for the pathologist to determine the primary focus, and tests such as immunohistochemistry can assist in the diagnosis. Early and accurate diagnosis and multidisciplinary treatment are conducive to improving the prognosis of patients.

2024-10-30 | PXD057417 |

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data