Long-range chromatin interactions in mouse embryonic stem cells identified by ChIA-PET [ChIA-PET]

ABSTRACT: The pluripotent state of embryonic stem cells (ESCs) is produced by active transcription of cell identity genes and repression of genes encoding lineage-specifying developmental regulators. Here we use large ESC cohesin ChIA-PET datasets and other genomic data to identify the local chromosomal structures at both active and repressed genes across the genome. The results show that super-enhancer driven cell identity genes generally occur within large loops that are connected through CTCF-CTCF interaction sites occupied by cohesin.

ORGANISM(S): Mus musculus

PROVIDER: GSE57911 | GEO | 2014/06/27

SECONDARY ACCESSION(S): PRJNA248406

REPOSITORIES: GEO