Transcriptomics

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Expression data for Control and SMRT-Depleted MCF-7 Cells


ABSTRACT: Estrogens are an important regulator of breast cancer disease progression, and they function by binding the estrogen receptor-α (ERα) to regulate changes in gene expression. ERα is able to both activate and inhibit gene transcription in a gene-specific manner and do so by binding target DNA sequences and recruiting coactivators and corepressors which can modulate the chromatin environment. Silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) is known to act as coactivator and corepressor of ERα in a gene-specific manner. We used a microarray analysis to examine the gene expression changes that occur when the coregulator SMRT is depleted from the ERα positive MCF-7 breast cancer cell line.

ORGANISM(S): Homo sapiens

PROVIDER: GSE57935 | GEO | 2014/06/21

SECONDARY ACCESSION(S): PRJNA251372

REPOSITORIES: GEO

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