Transcriptomics

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KRAS-induced transcription analysis in immortalized pancreatic cells


ABSTRACT: We utilized non-transformed, human pancreatic ductal epithelial (HPDE) cells, previously engineered with the E6 and E7 proteins of the HPV16 virus to emulate loss of p53 and inactivation of the Rb pathway, respectively. Given the frequent activation of KRAS (>90% PDAC tumors) and its early role in pancreatic neoplasia, we sought to engineer HPDE cells containing KRASG12D to provide the appropriate context in which to screen for novel drivers that might represent KRAS effectors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE58055 | GEO | 2016/01/19

SECONDARY ACCESSION(S): PRJNA248764

REPOSITORIES: GEO

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