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Polyglutamine expansion in TBP alters transcription in cellular model of SCA17

ABSTRACT: The poorly conserved N-terminal half of TATA binding protein (TBP) harbours a polyglutamine stretch of 29 to 42 in normal individuals. Expansion of this stretch leading to more than 42 is associated with a neurodegenerative disorder spinocerebellar ataxia 17 (SCA17). This study compares the espression profile of mouse neuro 2a cells expressing a vector control and TBP varient with 59 polyglutamines known to form intra nuclear aggregates. Keywords: Neuro 2a, SCA17, TBP, polyglutamine

ORGANISM(S): Mus musculus

PROVIDER: GSE5807 | GEO | 2007/12/08

SECONDARY ACCESSION(S): PRJNA97183

REPOSITORIES: GEO

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