Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression during tumor enhancement by 3,3’-diindolylmethane in rainbow trout

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Oncorhynchus mykiss

PROVIDER: GSE5813 | GEO | 2006/12/31

SECONDARY ACCESSION(S): PRJNA97195

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression during tumor enhancement by 3,3’-diindolylmethane in rainbow trout: Timecourse

Project description:Indole-3-carbinol (I3C) and 3,3’-diindolylmethane (DIM), a primary I3C derivative in vivo, are known dietary chemopreventive agents also available as dietary supplements. However, I3C has been found to act as a tumor promoter in rat (multi-organ) and trout (liver) models. I3C and DIM were previously found to be estrogenic in trout liver based on toxicogenomic profiles. In this study, we compare the post-initiation effects of DIM and 17β-estradiol (E2) on aflatoxin B1 (AFB1)-induced hepatocarcinogenesis in trout. Trout were initiated as embryos with 50 ppb AFB1, fed control diet for three months followed by diets containing 0, 120 or 400 ppm DIM or 5 ppm E2 for 18 weeks before returning all groups to control diet. Tumor incidence was determined 13 months later and found to be significantly elevated in AFB1-initiated trout fed either 400 ppm DIM or 5 ppm E2 compared to control animals. To evaluate the mechanism of tumor enhancement, hepatic gene expression profiles were examined in animals fed promotional diets during the course of tumorigenesis and in hepatocellular carcinomas (HCCs) of initiated animals using a rainbow trout 70-mer custom oligonucleotide array. We demonstrate that DIM alters gene expression profiles similar to E2 in liver samples during tumorigenesis and in HCC tumors. Further, HCCs from animals on DIM and E2 promotional diets had a transcriptional signature indicating decreased invasive or metastatic potential compared to HCCs from control animals. Overall, these findings are the first to demonstrate tumor promotion by DIM. They confirm the importance of estrogenic signaling in the mechanism of promotion by dietary indoles in trout liver and indicate a possible dual effect that enhances tumor incidence and decreases potential for metastasis. Keywords: time course

2006-12-31 | GSE5644 | GEO

Gene expression during tumor enhancement by 3,3’-diindolylmethane in rainbow trout: HCC tumor samples

2006-12-31 | GSE5643 | GEO

Transcriptional and miRNA profiling during rainbow trout ovarian development

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-04-11 | E-GEOD-39590 | biostudies-arrayexpress

Transcriptional and miRNA profiling during rainbow trout ovarian development

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-04-11 | GSE39590 | GEO

Toxic effects of dietary methylmercury (MeHg) on rainbow trout and zebrafish

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-01 | E-GEOD-32431 | biostudies-arrayexpress

Gene expression and pathologic alteration in juvenile rainbow trout due to chronic dietary TCDD exposure

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-04-05 | E-GEOD-45781 | biostudies-arrayexpress

Differential gene expression of candidate genes for growth in rainbow trout

Project description:This SuperSeries is composed of the SubSeries listed below.

2012-11-29 | GSE42584 | GEO

Domestication causes large-scale effects on gene expression in rainbow trout

Project description:This SuperSeries is composed of the SubSeries listed below.

2009-07-03 | GSE16903 | GEO

Toxic effects of dietary methylmercury (MeHg) on rainbow trout and zebrafish

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-06-01 | GSE32431 | GEO

Gene expression and pathologic alteration in juvenile rainbow trout due to chronic dietary TCDD exposure

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-04-05 | GSE45781 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data