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Mice model for 15q11-13 duplication syndrome show late onset obesity and altered lipid metabolism

ABSTRACT: To investigate the gene expression change in the white adipose tissue (WAT) of patDp/+ mice compared with wild type mice, the whole genome microarray profiling was performed. Total RNA from WAT of young adult stage mice (9-10 weeks old) was extracted and subject to microarray analysis. Expression change of sfrp5 gene was further validated by real-time PCR, suggesting this gene might contribute to the obesity in patDp/+ mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE58191 | GEO | 2015/05/01

SECONDARY ACCESSION(S): PRJNA251538

REPOSITORIES: GEO

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Mice model for 15q11-13 duplication syndrome show late onset obesity and altered lipid metabolism

Project description:To investigate the gene expression change in the white adipose tissue (WAT) of patDp/+ mice compared with wild type mice, the whole genome microarray profiling was performed. Total RNA from WAT of young adult stage mice (9-10 weeks old) was extracted and subject to microarray analysis. Expression change of sfrp5 gene was further validated by real-time PCR, suggesting this gene might contribute to the obesity in patDp/+ mice. We measured the gene expression change in WAT of young adult stage mice. Three patDp/+ mice and threewild type mice were used in the experiment.

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