Transcriptomics

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NQO1 regulates inflammatory signaling


ABSTRACT: NQO1 silencing by a specific shRNA against NQO1 increased migration and hormone-independent survival in hormone-dependent human prostate cancer cells LNCaP. Genome wide array revealed that NQO1 blockade significantly upregulated pro-inflammatory mediators (e.g., IL-32, CCL2, IL-8, IL-17C, IL-10RA, CXCR2, CXCR7, NOS3) associated with prostate tumorigenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE58336 | GEO | 2014/08/26

SECONDARY ACCESSION(S): PRJNA252018

REPOSITORIES: GEO

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