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Axiom® Exome 319 Array data to identify susceptible genetic variations of gastric cancer

ABSTRACT: To efficiently identify genetic susceptibility variants for gastric cancer, including rare coding variants, we performed an exome chip-based array study. We found that a linkage disequilibrium (LD) block containing 2 significant variants in PSCA gene increased the risk and two blocks that included 15 suggested variants including TRIM31, TRIM 40, TRIM 10, and TRIM26 regions, and included one suggested variant and OR2H2 gene showed protective associations with gastric cancer susceptibility. In addition, the PLEC region (rs200893203), FBLN2 region (rs201192415), and EPHA2 region (rs3754334) were associated with increased susceptibility

ORGANISM(S): Homo sapiens

PROVIDER: GSE58356 | GEO | 2014/06/11

SECONDARY ACCESSION(S): PRJNA252114

REPOSITORIES: GEO

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Axiom® Exome 319 Array data to identify susceptible genetic variations of gastric cancer

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