Methylation profiling

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Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes


ABSTRACT: The study investigated the abberrent DNA methylation in correlation with gene expression in cytogenetic normal acute myeloid leukemia. CN-AML blasts isolated from patient bone marrow aspriation were compared to CD34+ cell population from healthy donors by DNA methylation array and affymetrix gene expression microarray.

ORGANISM(S): Homo sapiens

PROVIDER: GSE58477 | GEO | 2014/07/31

SECONDARY ACCESSION(S): PRJNA252724

REPOSITORIES: GEO

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