Transcriptomics

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Livers of mice fed an atherogenic diet for 6 or 24 weeks


ABSTRACT: To address the molecular basis for atherogenic diet-induced liver injury, we performed microarray analysis using livers at early (6 weeks) and pre-cirrhosis stages (24 weeks) in the development of steatohepatitis. The Atherogenic diet up-regulated the gene expression for fatty acid synthesis, inflammatory cytokines, oxidative stress, and fibrosis, and with down-regulation of fatty acid beta-oxidation. The addition of a high-fat component to the Atherogenic diet up-regulated the gene expression for fatty acid synthesis and transport pathways and down-regulated some of the antioxidant genes. Keywords: time-course

ORGANISM(S): Mus musculus

PROVIDER: GSE5852 | GEO | 2006/09/19

SECONDARY ACCESSION(S): PRJNA97259

REPOSITORIES: GEO

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