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Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh proliferating C2C12 Myoblasts

ABSTRACT: Knockdown of PRDM2 led to precocious differentiation. To understand the molecular basis for this phenotype, we performed microaary analysis of growing myoblasts. Genes differentially regulated by PRDM2 knock down were reveraled by microarray analysis using NIA15K mouse chips.

ORGANISM(S): Mus musculus

PROVIDER: GSE58675 | GEO | 2015/06/30

SECONDARY ACCESSION(S): PRJNA253137

REPOSITORIES: GEO

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Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh proliferating C2C12 Myoblasts

Project description:Knockdown of PRDM2 led to precocious differentiation. To understand the molecular basis for this phenotype, we performed microaary analysis of growing myoblasts. Genes differentially regulated by PRDM2 knock down were reveraled by microarray analysis using NIA15K mouse chips. Control and knock down cells were grown in proliferating conditions

2015-06-30 | E-GEOD-58675 | biostudies-arrayexpress

Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh differentiated C2C12 Myoblasts (D28hrs)

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Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh Quiescent C2C12 Myoblasts (G0 enriched)

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Identification of targets genes of PRDM2 in G0 arrested myoblasts of C2C12

Project description:PRDM2 directly associates with the Myogenin promoter and repress its transcription. This led to the hypothesis that PRDM2 could potentially associate directly with other promoters and regulate their expression.To gain further insight into the pathways and genes controlled by PRDM2, ChIP-on-Chip analysis was performed using mouse 44K promoter array. Since PRDM2 represses transcription by H3K9 dimethylation, we were interested in determining which targets were occupied by PRDM2 as well as showed enrichment for H3K9me2. Hence ChIP-on-Chip analysis for H3K9me2 was performed to find the overlap between PRDM2 and H3K9me2 marked promoters.

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Transcriptional profiling of MLL5 Knock down vs. control C2C12 myoblasts (S phase enriched)

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Project description:Gene expression profiling of PRDM2 Knockdown in proliferating, quiescent and differentiating myoblasts

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Transcriptional profiling of MLL5 Knock down vs. control C2C12 myoblasts (S phase enriched)

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