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Chromatin dynamics of p53 binding sites in IMR90

ABSTRACT: We report the chromatin modification dynamics at p53 binding sites upon treatment with DMSO or nutlin3-a (5uM) in IMR90 human lung fibroblasts using ChIP-seq and RNA-seq analyses. We assessed the genomewide changes in H3, H3K4me3, H3K4me2, H3K4me1, H3K27ac, H4K16ac, RNA polymerase II, and p53 in response to p53 activation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE58740 | GEO | 2014/11/12

SECONDARY ACCESSION(S): PRJNA253315

REPOSITORIES: GEO

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