Transcriptomics

Dataset Information

0

Effect of fbw7 deletion in mouse pancreatic ducts


ABSTRACT: The adult pancreas is capable of limited regeneration after injury, but has no defined stem cell population. The cell types and molecular signals that govern the production of new pancreatic tissue are not well understood. Here we show that inactivation of the SCF-type E3 ubiquitin ligase substrate recognition component Fbw7 induces pancreatic ductal cells to reprogram into β-cells. The induced β-cells resemble islet β-cells in morphology and histology, express genes essential for β-cell function, and release insulin upon glucose challenge. Thus, loss of Fbw7 appears to reawaken an endocrine developmental differentiation program in adult pancreatic ductal cells. Our study highlights the plasticity of seemingly differentiated adult cells, identifies Fbw7 as a master regulator of cell fate decisions in the pancreas, and reveals adult pancreatic duct cells as a latent multipotent cell type. We used microarray to compare adult mouse fbw7 knock out ductal cells with bonafide beta cells

ORGANISM(S): Mus musculus

PROVIDER: GSE58969 | GEO | 2014/08/07

SECONDARY ACCESSION(S): PRJNA254023

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-08-07 | E-GEOD-58969 | biostudies-arrayexpress
2015-12-31 | E-GEOD-76443 | biostudies-arrayexpress
2015-12-31 | GSE76443 | GEO
2008-06-11 | E-GEOD-11178 | biostudies-arrayexpress
2008-04-15 | GSE11178 | GEO
2021-09-02 | GSE138038 | GEO
2012-01-24 | E-GEOD-33322 | biostudies-arrayexpress
2016-07-03 | E-GEOD-72990 | biostudies-arrayexpress
2022-03-18 | GSE184040 | GEO
2015-05-01 | GSE59354 | GEO