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Expression data from Ezh2 conditional C2 iMEFs

ABSTRACT: Polycomb Repressive Complex 2 (PRC2) plays a key role in controlling transcriptional repression. It is thought to act at the level of the chromatin, where its enzymatic subunits Ezh1 and Ezh2 catalyse the di/tri-methylation of histone H3 on its lysine 27 (H3K27me3). We sought to assess several parameters of PRC2-mediated transcriptional repression. To this end we performed a comparative analysis of mES and iMEF cells following deletion of Ezh2, a time-course analysis following deletion of Ezh2 in iMEFs as well as rescue experiments with Ezh1 and Ezh2 before or after deletion of Ezh2.

ORGANISM(S): Mus musculus

PROVIDER: GSE59346 | GEO | 2015/10/01

SECONDARY ACCESSION(S): PRJNA255241

REPOSITORIES: GEO

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Genome-wide analysis of H3K27me3 in Ezh2-conditional iMEFs

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