Transcriptomics

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Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum


ABSTRACT: Purkinje cells (PC) of the cerebellum degenerate in adult mice with mutations in the Niemann-Pick type C (NPC) disease 1 (Npc1) gene. We subjected BALB/c Npc1+/+ and Npc1-/- mouse cerebella from an early and a later time point of PC degeneration to a genome-wide microarray gene expression analysis. We found general underrepresentation of PC-specific transcripts, consistent with PC loss, and elevated markers of microglia activation at the later time point. Keywords: Niemann-Pick type C, Purkinje cell degeneration

ORGANISM(S): Mus musculus

PROVIDER: GSE5944 | GEO | 2007/07/01

SECONDARY ACCESSION(S): PRJNA97395

REPOSITORIES: GEO

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