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Molecular profiling of three tumor subtypes in Ptch medulloblastomas

ABSTRACT: we discovered that medulloblastomas that form in Ptch mice are composed of three different sibtypes depending on the cell of origin and tumor progression. The goal was to identify gene signature that can distinguish the three subtypes

ORGANISM(S): Mus musculus

PROVIDER: GSE59560 | GEO | 2014/07/19

SECONDARY ACCESSION(S): PRJNA255633

REPOSITORIES: GEO

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Molecular profiling of three tumor subtypes in Ptch medulloblastomas

Project description:we discovered that medulloblastomas that form in Ptch mice are composed of three different sibtypes depending on the cell of origin and tumor progression. The goal was to identify gene signature that can distinguish the three subtypes RNA from tumor tissues from the three subtypes were extracted by Trizol and hybridized on Affy St1.0 chips for analysis

2014-07-19 | E-GEOD-59560 | biostudies-arrayexpress

Gene expression data from postnatal day 7 subventricular zone (SVZ), IV ventricle and cerebellar white matter-derived neural stem cells (NSCs) and of cancer stem cells (CSCs) from Ptch het p53 wt and Ptch het p53 het mouse medulloblastomas

Project description:We exploited microarrays to detail the global program of gene expression underlying normal stem cells and cancer stem cells in the cerebellum and in medulloblastomas (MBs). To identify novel molecular mediators involved in medulloblastomagenesis, we compared the distinct postnatal hindbrain-derived NSC populations, which are potentially tumor-initiating, with murine single Ptch and compound Ptch/p53-mutant MB cancer stem cells (CSCs), the latter faithfully phenocopying the different variants of human MB in vivo. Transcriptome analysis of both hindbrain NSCs and MB CSCs resulted in the generation of well-defined gene signatures, each reminiscent of a specific human MB molecular subclass.

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Project description:Molecular profiling of three tumor subtypes in Ptch medulloblastomas

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Medulloblastoma tumors derived from Ptch+/-p53-/- transgenic mouse allografted in nude mice

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Medulloblastoma tumors derived from Ptch+/-HIC+/- transgenic mouse allografted in nude mice

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Project description:We exploited microarrays to detail the global program of gene expression underlying normal stem cells and cancer stem cells in the cerebellum and in medulloblastomas (MBs).

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Medulloblastoma tumors derived from Ptch+/-HIC+/- transgenic mouse allografted in nude mice

Project description:Nude mice were allografted with medulloblastoma tumors derived from Ptch+/-HIC+/- transgenic mouse and treated with vehicle or NVP-LDE225. RNA was prepared from tumours from vehicle or NVP-LDE225 treated nude mice allografted with medulloblastoma tumors derived from Ptch+/-HIC+/- transgenic mouse and hybridized on the Affymetrix Mouse Genome 430A 2.0 RNA expression microarray.

2010-09-29 | E-GEOD-22005 | biostudies-arrayexpress

Medulloblastoma tumors derived from Ptch+/-p53-/- transgenic mouse allografted in nude mice

Project description:Nude mice were allografted with medulloblastoma tumors derived from Ptch+/-p53-/- transgenic mouse and treated with vehicle or NVP-LDE225. RNA was prepared from tumours from vehicle or NVP-LDE225 treated nude mice allografted with medulloblastoma tumors derived from Ptch+/-p53-/- transgenic mouse and hybridized on the Affymetrix Mouse Genome 430A 2.0 RNA expression microarray.

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Ptch1+/- Nos2-/- medulloblastomas

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