Genomics

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Gene and microRNA expression profiling of breast tumors from Chinese and Italian women [miRNA]


ABSTRACT: Gene and miRNA profiles from a unique Chinese/Caucasian trans-ethnic collection of breast cancer from Shanghai (China) and Milan (Italy) were compared using an unsupervised approach that identified similar clusters of correlated features in Chinese and Caucasian datasets. Partition of gene expression data using previously published gene signatures, such as the PAM50 intrinsic gene list and the extracellular matrix (ECM) genes, revealed Chinese and Caucasian subgroups with equivalent gene and miRNA expression profiles. A significant reduction of Luminal-A tumors was observed in the Chinese series.

ORGANISM(S): Homo sapiens

PROVIDER: GSE59594 | GEO | 2015/03/31

SECONDARY ACCESSION(S): PRJNA255672

REPOSITORIES: GEO

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