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NB4 cells treated with lethal toxin

ABSTRACT: Bacillus anthracis lethal toxin (LT) exposure on NB-4 cells Keywords: time course

ORGANISM(S): Homo sapiens

PROVIDER: GSE5966 | GEO | 2006/10/07

SECONDARY ACCESSION(S): PRJNA97433

REPOSITORIES: GEO

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Transcription profiling of human NB4 cells treated with lethal Bacillus anthracis toxin

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| PRJNA113493 | ENA

Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocyte.

Project description:Anthrax lethal toxin directly targets human peripheral monocytes and causes multiple aberrant gene responses that would be expected to result in defects in human monocyte’s normal signaling transduction pathways and nction. This study provides further insights into the mechanisms associated with the host immune system collapse during an anthrax infection, and suggests that anthrax LT may have additional targets outside the well-known MAPK pathway.

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