Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression analysis of Influenza vaccine response in Young and Old - Year 3 - PBMC

ABSTRACT: We profiled gene expression of PBMC from a stratified cohort of subjects to define influenza vaccine response in Young and Old

ORGANISM(S): Homo sapiens

PROVIDER: GSE59743 | GEO | 2017/03/01

SECONDARY ACCESSION(S): PRJNA256094

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression analysis of Influenza vaccine response in Young and Old - Year 1 - PBMC

Project description:We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old

2015-01-26 | GSE59635 | GEO

Gene expression analysis of Influenza vaccine response in Young and Old - Year 2 - PBMC

Project description:We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old

2015-01-26 | GSE59654 | GEO

Gene expression analysis of Influenza vaccine response in Young and Old - Year 5

Project description:We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old

2019-05-26 | GSE101710 | GEO

Gene expression analysis of Influenza vaccine response in Young and Old - Year 4

Project description:We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old

2020-01-08 | GSE101709 | GEO

Gene expression analysis of Influenza vaccine response in Young and Old - Year 1

Project description:We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old Differential gene expression by human PBMCs from Healthy Adults receiving Influenza Vaccination (Fluvirin, Novartis). Healthy adults (older >65, younger 21-30 years) were recruited at seasonal Influenza Vaccination clinics organized by Yale University Health Services during October to December of 2010 M-bM-^@M-^S 2011 and 2011-2012 seasons. With informed consent, healthy individuals were recruited as per a protocol approved by Human Investigations Committee of the Yale University School of Medicine. Each subject was evaluated by a screening questionnaire determining self-reported demographic information, height, weight, medications and comorbid conditions. Participants with acute illness two weeks prior to vaccination were excluded from study. Blood samples were collected into BD Vacutainer Sodium Heparin tube at four different time points, once prior to administration of vaccine and three time points after vaccination on days 2/4, 7 and 28. Peripheral Blood Mononuclear Cells (PBMC) were isolated from heparinized blood using Histopaque 1077 in gradient centrifugation. About 1.0x10^7 freshly isolated PBMC were lysed in Triso and immediately stored in -800C. Total RNA in aqueous phase of Trisol - Chloroform was isolated in an automated QiaCube instrument using miRNeasy according to manufacturerM-bM-^@M-^Ys instructions. Integrity of RNA samples were assessed by Agilent 2100 BioAnalyser Samples were processed for cRNA generation using Illumina TotalPrep cRNA Amplification Kit and subsequently hybridized to Human HT12-V4.0 BeadChip at Yale Center for Genomic Analysis (YGCA).

2015-01-26 | E-GEOD-59635 | biostudies-arrayexpress

Gene expression analysis of Influenza vaccine response in Young and Old - Year 2

2015-01-26 | E-GEOD-59654 | biostudies-arrayexpress

Gene expression analysis of Influenza vaccine response in Young and Old - Year 1 - B and T cells

Project description:We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old.

2020-01-08 | GSE65440 | GEO

Gene expression analysis of Influenza vaccine response in Young and Old - Year 2 - B and T cells

Project description:We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old.

2020-01-08 | GSE65442 | GEO

Gene expression analysis of Influenza vaccine response in Young and Old - Year 3 - B and T cells

Project description:We profiled gene expression of B and T cells from a stratified cohort of subjects to define influenza vaccine response in Young and Old

2020-01-08 | GSE95584 | GEO

Gene expression profiles associated with humoral response to influenza vaccine, Vaxigrip, in young and elderly subjects of Chinese ethnicity in Singapore

Project description:While studying influenza vaccine-induced responses, the elderly are typically considered as a homogeneous population. However, chronological age alone is insufficient in defining immune responsiveness of individuals. In this study, a stratified cohort of elderly (65 year old and above) and young (below 35 year old) individuals was recruited to study the heterogeneity of influenza vaccine-induced responses and identify innate signatures including gene expression profiles defining vaccine immunogenicity. The study was conducted in Singapore, a tropical setting without well-defined influenza seasons.

2018-11-14 | GSE107990 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data