Transcriptomics

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Calcineurin-dependent transcriptome in ICN1 (activated NOTCH1)-induced T cell acute lymphoblastic leukemia (T-ALL)


ABSTRACT: Activated NOTCH1 induces T-ALL in mice when transduced in bone marrow (BM) cells. T-ALL cells activate the calcineurin/NFAT pathway in vivo (Medyouf H. et al. Nat Med 2007 [PMID 17515895]). Through appropriate crosses, mouse ICN1-induced T-ALL were generated that include a ROSCreERT2 transgene and 2 copies of a CnB1 floxed alleles.

ORGANISM(S): Mus musculus

PROVIDER: GSE60258 | GEO | 2014/08/09

SECONDARY ACCESSION(S): PRJNA257825

REPOSITORIES: GEO

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