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Expression data in MDA-MB-231 cells treated with siATM, sip53 or control (SiNC) siRNA

ABSTRACT: Ataxia-telangiectasia mutated (ATM) protein kinase regulates the DNA damage response and is associated with cancer suppression. Here, we used microarray to study global transcriptomic expression to identify tumor-promoting functions of ATM.

ORGANISM(S): Homo sapiens

PROVIDER: GSE60479 | GEO | 2014/08/18

SECONDARY ACCESSION(S): PRJNA258379

REPOSITORIES: GEO

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Expression data in MDA-MB-231 cells treated with siATM, sip53 or control (SiNC) siRNA

Project description:Ataxia-telangiectasia mutated (ATM) protein kinase regulates the DNA damage response and is associated with cancer suppression. Here, we used microarray to study global transcriptomic expression to identify tumor-promoting functions of ATM. Human breast cancer MDA-MB-231 cells were transfected with siATM, sip53 or control siRNA followed by RNA extraction and hybridization on Affymetrix GeneChip Human Gene 2.0 ST array.

2014-08-18 | E-GEOD-60479 | biostudies-arrayexpress

Transcription profiling of ATM +/+, ATM +/- and ATM -/- human lymphoblastoid cell lines exposed to 5 Gy IR at 0, 4 and 24 hours to identify expression phenotypes in Ataxia Telangiectasia carriers and patients

Project description:Transcription profiling of ATM (Ataxia Telangiectasia Mutated) +/+ (Control), ATM +/- (AT Carrier) and ATM -/- (AT patient) human lymphoblastoid cell lines exposed to 5 Gy IR at 0, 4 and 24 hours to identify expression phenotypes in Ataxia Telangiectasia carriers and patients

2008-07-29 | E-TABM-321 | biostudies-arrayexpress

Expression data in MDA-MB-231 cells treated with siATM, sip53 or control (SiNC) siRNA

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PGSC0003DMG400026995

Project description:Solanum tuberosum PGSC0003DMG400026995, ATM (ATAXIA-TELANGIECTASIA MUTATED) [Source:PGSC_GENE;Acc:PGSC0003DMG400026995], is expressed in 1 baseline experiment(s);

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Project description:ATM (ataxia telangiectasia mutated) kinase is crucial to a wide range of human developmental disorders and adult/pediatric malignancies. Its mutations are causally tied to ataxia telangiectasia, a multi-systemic congenital disorder mainly affecting brain and blood systems. We generated 4 separate ATM-knockout human pluripotent stem cell lines and differentiated them to form 3-dimensional brain cortical brain organoids. Brain cortical organoids are an excellent model of human developing cortex. Using these analyses, we identified ATM-dependent phosphorylation predominantly influences factors in neurogenesis, neuronal differentiation, cell morphogenesis, and microtubule cytoskeleton as well as kinases involved in ATM, BNDF, and WNT signaling, G2/M checkpoint, and p53 regulation. These findings have broad implications about diseases associated with ATM, including ataxia telangiectasia.

2024-07-25 | PXD041699 | Pride

ENSG00000232418

Project description:Homo sapiens ENSG00000232418, pseudogene similar to part of ataxia telangiectasia mutated ATM, is expressed in 7 baseline experiment(s);

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ENSG00000232418

Project description:Homo sapiens ENSG00000232418, pseudogene similar to part of ataxia telangiectasia mutated ATM, is differentially expressed in 1 experiment(s);

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Project description:Mus musculus Atm, ataxia telangiectasia mutated [Source:MGI Symbol;Acc:MGI:107202], is differentially expressed in 104 experiment(s);

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Project description:Mus musculus Atm, ataxia telangiectasia mutated [Source:MGI Symbol;Acc:MGI:107202], is expressed in 36 baseline experiment(s);

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Transcription profiling of atm mutant, adm mutant and wild type whole plants and roots of Arabdiposis after gamma ray irradiation in a time series

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