Transcriptomics

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Higher maternal folic acid during gestation dysregulates expression of several genes in mice offspring cerebellum


ABSTRACT: Maternal vitamins and micronutrients during gestational periods have profound impact on the developmemt of newborns as well as influence susceptibility to chronic conditions. Folic acid is indicated to women during pregnancies to prevent occurrence of neural tube defects in infants. Recently, evidence is emerging of the epigenetic effects of folic acid. Since epigenetic changes are crucial in developing fetus, we investigated the effect of maternal higher folic acid supplementation on the gene expression in offspring brains to identify if brain development may be affected. Our results revealed that maternal exposure of higher dose FA diet during gestation dysregulates expression of several genes in the cerebellum of both male and female pups. Dysregulated genes included several transcriptional factors, imprinted genes, neurodevelopmental genes and genes associated with autism spectrum disorder.

ORGANISM(S): Mus musculus

PROVIDER: GSE60531 | GEO | 2015/01/26

SECONDARY ACCESSION(S): PRJNA258475

REPOSITORIES: GEO

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