Transcriptomics

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Micro-RNAs expressed in oligometastases inhibit genes involved with adhesion, invasion and motility


ABSTRACT: Analysis of MDA-MB-231 cells 48 hours after transfection with non-targeting control, micro-RNA mimics or corresponding micro-RNA inhibitor. The hypothesis tested was that micro-RNAs previously identified as expressed in oligometastatic patients' metastases at a higher level than polymetastatic patients' metastases suppress genes regulating adhesion, motility, invasion and growth. Results showed that multiple micro-RNAs can suppress multiple genes involved in these pathways.

ORGANISM(S): Homo sapiens

PROVIDER: GSE60766 | GEO | 2015/03/01

SECONDARY ACCESSION(S): PRJNA259511

REPOSITORIES: GEO

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