Coordinate Regulation of Enhancer Transcription at Super-Enhancers
Ontology highlight
ABSTRACT: Using GRO-Seq, we find extensive regulation of enhancer RNAs (eRNA) within super-enhancers in response to lipopolysaccharide treatment in macrophages. Both activation and repression of gene expression are associated with super-enhancers and eRNA transcription dynamics. Treatment of macrophages with LPS targeted specific super-enhancers by attenuating their eRNA expression, leading to expression of key inflammatory genes. We propose that super-enhancers function as molecular rheostats integrating the binding profiles of key regulators to produce dynamic profiles of gene expression.
ORGANISM(S): Mus musculus
PROVIDER: GSE60857 | GEO | 2014/12/25
SECONDARY ACCESSION(S): PRJNA259674
REPOSITORIES: GEO
ACCESS DATA