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Gene expression changes in limb buds of Nipbl-haploinsufficient mice

ABSTRACT: Multiple genes are dysregulated in hindlimb buds of Nipbl-deficient embryos. In all, more than 1000 limb bud genes were found to be significantly altered in expression by microarray analysis of E10.5 mouse hindlimb buds. Small changes in expression (mostly decreases) were observed for genes involved in FGF, BMP, and SHH pathways, as well as numerous genes involved in the Wnt/planar cell polarity signaling pathway. Genes involved in the Mediator complex, Cohesin function, and Hox gene expression and functions were also dysregulated in Nipbl deficient limb buds.

ORGANISM(S): Mus musculus

PROVIDER: GSE60932 | GEO | 2014/08/30

SECONDARY ACCESSION(S): PRJNA259854

REPOSITORIES: GEO

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Gene expression changes in limb buds of Nipbl-haploinsufficient mice

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Project description:Gene expression changes in limb buds of Nipbl-haploinsufficient mice

| PRJNA259854 | ENA

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