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Alteration of mRNA and microRNA expression profiles in rat muscular type vasculature in early postnatal development [mRNA]

ABSTRACT: This study tested the hypothesis that mRNA expression profiles change in the muscular type rat saphenous artery during early postnatal development. To explore this, we performed mRNA microarray analysis on muscular type saphenous arteries of young (10-12 days) and adult (2-3 months) rats.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE60961 | GEO | 2015/04/30

SECONDARY ACCESSION(S): PRJNA259969

REPOSITORIES: GEO

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Alteration of mRNA and microRNA expression profiles in rat muscular type vasculature in early postnatal development [mRNA]

Project description:This study tested the hypothesis that mRNA expression profiles change in the muscular type rat saphenous artery during early postnatal development. To explore this, we performed mRNA microarray analysis on muscular type saphenous arteries of young (10-12 days) and adult (2-3 months) rats. For one sample four saphenous arteries from 2 young animals (n = 4 samples per group) or two saphenous arteries from one adult animal (n = 4 samples per group) were used to profile mRNA (n = 8; GeneChip® Rat Gene 1.0) expression changes during the muscular type rat saphenous artery during early postnatal development. In this study, 10-12 days old (“young”) and 2 - 3 months old (“adult”) male Wistar rats.

2015-04-30 | E-GEOD-60961 | biostudies-arrayexpress

Alteration of mRNA and microRNA expression profiles in rat muscular type vasculature in early postnatal development [miRNA]

Project description:This study tested the hypothesis that miRNA expression profiles change in the muscular type rat saphenous artery during early postnatal development. To explore this, we performed miRNA microarray analysis on muscular type saphenous arteries of young (10-12 days) and adult (2-3 months) rats. For one sample four saphenous arteries from 2 young animals (n = 4 samples per group) or two saphenous arteries from one adult animal (n = 4 samples per group) were used to profile miRNA (n = 8; GeneChip® miRNA 3.0) expression changes during the muscular type rat saphenous artery during early postnatal development. In this study, 10-12 days old (“young”) and 2 - 3 months old (“adult”) male Wistar rats were used.

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2015-04-30 | GSE60962 | GEO

Alteration of mRNA and microRNA expression profiles in rat muscular type vasculature in early postnatal development.

Project description:The vascular system is characterized by a high degree of plasticity. In particular, functional and structural remodeling of the arterial system takes place during early postnatal development. However, the mechanisms providing such alterations in the rapidly growing organisms are poorly understood, especially for the peripheral vasculature. To explore this, we performed mRNA- and miRNA microarray analysis on muscular type saphenous arteries of young (10-12 days) and adult (2-3 months) rats. Thirty-eight significant pathways (such as oxidative phosphorylation, MAPK signaling, metabolism, cell cycle, DNA replication and focal adhesion) were obtained on differentially regulated genes during postnatal development. Many differentially regulated genes were determined as target- and miRNA-hubs. We also found 92 miRNAs differentially expressed in arteries of young and adult rats. Several significantly regulated pathways were found on these regulated miRNAs. Interestingly, these biological cascades also contain those significantly enriched pathways that were previously identified based on the differently expressed genes. Our data indicate that the expression of many genes involved in the regulation of pathways that are relevant for different functions in arteries may be under the control of miRNAs and these miRNAs regulate the functional, and structural remodeling occurring in the vascular system during early postnatal development.

| S-EPMC4466593 | biostudies-literature

Alteration of mRNA and microRNA expression profiles in rat muscular type vasculature in early postnatal development

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-04-30 | E-GEOD-60963 | biostudies-arrayexpress

Alteration of mRNA and microRNA expression profiles in rat muscular type vasculature in early postnatal development

Project description:This SuperSeries is composed of the SubSeries listed below.

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Proteomic profiling of tissue-engineered, small-diameter vascular grafts implanted into the ovine carotid artery

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Gene expression in a resistance artery in 2 models of hypertension in the rat

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