Gene expression profiles of desmoid tumor cells treated with gamma-secretase inhibitor
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ABSTRACT: Desmoid tumors (DTs) are rare mesenchymal monoclonal lesions that have a high risk of local recurrence but lack metastatic potential. Since the Notch pathway appears to be important in the carcinogenesis of several tumor types, in the past few years γ-secretase inhibitors (GSIs) have emerged as a potential therapeutic treatment by inhibiting cancer cell Notch signaling through NICD cleavage blockade. To investigate the antitumor effect of PF-03084014, a γ-secretase inhibitor, in DT models, cells treated with PF-03084014 were characterized by gene array analysis.
ORGANISM(S): Homo sapiens
PROVIDER: GSE61097 | GEO | 2015/11/03
SECONDARY ACCESSION(S): PRJNA260216
REPOSITORIES: GEO
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