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Thalidomide induced early gene expression perturbations indicative of human embryopathy in mouse embryonic stem cells

ABSTRACT: To unravel the mechanisms of thalidomide developmental toxicity, we used microarrays to study transcriptomic changes induced by thalidomide during mouse embryonic stem cell (mESC) differentiation. C57BL/6 mESCs were allowed to differentiate spontaneously and global gene expression changes were studied using microarrays at at different time points after exposure to 0.25 mM thalidomide (THD).

ORGANISM(S): Mus musculus

PROVIDER: GSE61306 | GEO | 2015/05/31

SECONDARY ACCESSION(S): PRJNA260719

REPOSITORIES: GEO

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Transcriptomic characterization of C57BL/6 mouse embryonic stem cell differentiation and its modulation by developmental toxicants

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Transcriptomic characterization of C57BL/6 mouse embryonic stem cell differentiation and its modulation by developmental toxicants

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MOF-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation [array]

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