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Transcriptional changes in the aging mouse hippocampus (RNA-seq)

ABSTRACT: We sequenced mRNA from three age groups (3months (3M), 24 months (24M) and 29 months (29M)) from the full hippocampus

ORGANISM(S): Mus musculus

PROVIDER: GSE61915 | GEO | 2014/10/01

SECONDARY ACCESSION(S): PRJNA262674

REPOSITORIES: GEO

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Transcriptional Changes in the Aging Mouse Hippocampus (expression)

Project description:We sequenced mRNA from three age groups (3months (3M), 24 months (24M) and 29 months (29M)) from the full hippocampus and compared this to microarray analysis.

2014-09-23 | GSE61647 | GEO

Transcriptional Changes in the Aging Mouse Hippocampus

Project description:We sequenced mRNA from three age groups (3months (3M), 24 months (24M) and 29 months (29M)) from the full hippocampus and compared this to microarray analysis. Young (3 months (3M)) mice were compared to aged mice (29 months (29M)), n=4

2014-09-23 | E-GEOD-61647 | biostudies-arrayexpress

Transcriptional changes in the aging mouse hippocampus (RNA-seq)

Project description:We sequenced mRNA from three age groups (3months (3M), 24 months (24M) and 29 months (29M)) from the full hippocampus There were two independent experiments: 3M vs 24M (n=5 to 6, single-end sequencing) and 3M vs 29M (n=3, paired-end sequencing))

2014-10-01 | E-GEOD-61915 | biostudies-arrayexpress

Myristic acid alleviates hippocampal aging via regulating GABAergic expressions

Project description:To evaluate differentially expressed genes and pathways in hippocampus between young (3-month-old, 3M) and aging (22-month-old, 22M) group. We then performed gene expression profiling analysis using data obtained from mRNA-seq in hippocampus of 3M and 22M group.

2022-04-21 | GSE201029 | GEO

Focal adhesion and NRF2 pathway regulate left-right asymmetries of rhesus hippocampus aging: relevance to human hippocampus aging and Alzheimer’s disease

Project description:Left-right asymmetry is a basic character of aging brain; however, the molecular foundation of the left-right asymmetry remains unclear. The morphology, physiology and behavior of rhesus aging are obviously similar to human aging, but the aging-rate of rhesus is roughly three times as fast as human, in which the underlying mechanism needs further investigation. By using of 6-plex tandem mass tag (TMT) labeling, we presented a high throughput quantitative proteomics analysis to 6 group hippocampal samples including left and right hippocampus from 3 years, 6 years and 20 years old rhesus. Our data identified 3391 high-confidence proteins. After screening, we found 340 aging-related proteins of left hippocampus and 334 aging-related proteins of right hippocampus, in which there were 114 overlap proteins. Furthermore, the aging-related proteome of left rhesus hippocampus aging was compared with human aging-related proteome of left hippocampus that was reported by our lab previously. As the results show, we discovered 446 aging-related proteins in rhesus and 830 aging-related proteins in human with an overlap of 106 proteins.

2020-01-23 | PXD011398 | Pride

Learning and age-related changes in genome-wide H2A.Z binding in the hippocampus

Project description:We characterize histone H2A.Z binding and RNA expression in the hippocampus of young (2.5 months) and aged (15.5 months) mice in response to contextual fear conditioning.

2018-01-10 | GSE100039 | GEO

Identification of CaMKII splice variants expressed in the human hippocampus

Project description:Purpose: The goal of this study was to use deep sequencing to identify all splice variants of Calcium/calmodulin-dependent kinase II (CaMKII) expressed in the human hippocampus. Methods: Transcripts of CaMKII-encoding genes (CAMK2A, CAMK2B, CAMK2G, and CAMK2D) were sub-amplified by PCR from total RNA extracted from human hippocampal tissue samples from 3 donors. Illumina sequencing libraries were constructed by PCR from these initial pools of amplicons and sequenced on an Illumina MiSeq instrument. Sequencing reads passing quality controls were clustered on the basis of sequence identity or near-identity. Consensus sequences of clusters were mapped with known exons of CaMKII genes to identify the splice variant represented by each cluster. Donor 1 replicate 2, Donor 2, and Donor 3 libraries from genes CAMK2B, CAMK2G, and CAMK2D were first sequenced on a MiSeq Nano flow cell, then re-pooled for read balancing and sequenced again of a full-size MiSeq flow cell. For each library, reads from Nano and full-size flow cells were combined for subsequent analysis. Results: We perfomed the first comprehensive survey of CaMKII transcripts expressed in individual tissue samples (human hippocampus). We detected a total of 79 splice variants of the four human CaMKIIs: CaMKIIα (3), CaMKIIβ (30), CaMKIIγ (24), and CaMKIIδ (22), across tissue samples from 3 donors. This represents the vast majority of possible in-frame CaMKII splice variants (Sloutsky and Stratton, European Journal of Neuroscience, 2020; https://doi.org/10.1111/ejn.14761).

2020-07-21 | GSE154030 | GEO

Gene expression in mouse hippocampus in response to long-term calorie restriction

Project description:The effect of a long-term calorie restricted diet was evaluated in hippocampus of male mice The dietary intervention was initiated at 14 months of age and continued until 30 months of age

2021-11-25 | GSE64226 | GEO

total RNA-seq from layer of hippocampus (ENCSR330DDD)

Project description:hippocampus B6Cast F1 2 months male For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2021-11-04 | GSE187051 | GEO

total RNA-seq from layer of hippocampus (ENCSR912TCG)

Project description:hippocampus B6Cast F1 2 months female For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2021-11-04 | GSE188086 | GEO

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