Transcriptomics

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Expression data of untreated or cisplatin-treated wildtype or Rb-/- MEFs


ABSTRACT: The absence of the Rb tumor suppressor gene changes levels/activities of transcription factors (e.g., E2F and p53) which alter gene expression patterns, related to cell cycle control and cellular response to DNA damage. Cisplatin is a genotoxic chemotherapeutic agent and wildtype or Rb null cells have different sensitivities to cisplatin-induced cytotoxicity. We used microarrays to compare global profiles of gene expression and distinct responses of wildtype and Rb null MEFs in response to cisplatin. Keywords: genotype and cisplatin treatment

ORGANISM(S): Mus musculus

PROVIDER: GSE6206 | GEO | 2007/09/01

SECONDARY ACCESSION(S): PRJNA100621

REPOSITORIES: GEO

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