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Secondary proteasome inhibitor carfilzomib resistant myeloma cell lines

ABSTRACT: Modulation of the activity of the ubiquitin-proteasome pathway with the proteasome inhibitor (PI) is an established component of therapy for plasma cell disorders. However, resistance emerges and the mechanism is incompletely understood. We generated carfilzomib-resistant (CR) myeloma cell lines by exposing drug-naive ANBL-6, KAS-6/1, U266, and OPM-2 cells to increasing concentrations of carfilzomib and then performed gene expression profiling (GEP) to identify prominent changes compared to their vehicle-treated counterparts, followed by exploration of the mechanism(s) of proteasome inhibitor resistance.

ORGANISM(S): Homo sapiens

PROVIDER: GSE62237 | GEO | 2016/10/09

SECONDARY ACCESSION(S): PRJNA263564

REPOSITORIES: GEO

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