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Profiling of serum and urinary microRNAs in children with atopic dermatitis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE62406 | GEO | 2014/10/17

SECONDARY ACCESSION(S): PRJNA264025

REPOSITORIES: GEO

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Profiling of serum and urinary microRNAs in children with atopic dermatitis

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-10-17 | E-GEOD-62406 | biostudies-arrayexpress

Profiling of serum and urinary microRNAs in children with atopic dermatitis.

Project description:BackgroundAtopic dermatitis (AD) is the most prevalent chronic inflammatory skin disease in children characterized by dermatitis and pruritus. MicroRNAs (miRNAs) have been shown as great potential biomarkers for disease fingerprints to predict prognostics. We aimed to identify miRNA signature from serum and urine for the prognosis of AD patient by genome-wide miRNA profiling analysis.MethodsSerum and urine from 30 children with AD and 28 healthy children were collected and their genome-wide miRNA expression profiles were measured by TaqMan-based array and confirmed by quantitative real-time PCR. Inflammatory factors in serum were detected by Antibody Array System.ResultsmiR-203 and miR-483-5p were significantly up-regulated in serum of children with AD compared with healthy children. The level of miR-483-5p in serum was significantly associated with other atopic conditions, such as rhinitis and/or asthma. However, miR-203 was markedly decreased in urine of children with AD compared with healthy children. Down-regulated miR-203 in urine was significant associated with abnormal level of serum IgE in AD patients. 7 inflammatory factors in serum were altered in children with AD compared with healthy children. Up-regulated miR-203 in serum was significantly associated with increased sTNFRI and sTNFRII.ConclusionsUp-regulated miR-483-5p in serum may be indicative of other atopic conditions in children with AD. Down-regulated miR-203 in urine may serve as a biomarker for the severity of inflammation in children with AD.

| S-EPMC4274001 | biostudies-literature

Profiling of urinary microRNAs in children with atopic dermatitis

Project description:Atopic dermatitis (AD) is the most prevalent chronic inflammatory skin disease in children characterized by dermatitis and pruritus. MicroRNAs (miRNAs) have been shown as great potential biomarkers for disease fingerprints to predict prognostics. We aimed to identify miRNA signature from serum and urine for the prognosis of AD patient by genome-wide miRNA profiling analysis.

2014-10-17 | GSE62403 | GEO

Profiling of urinary microRNAs in children with atopic dermatitis

2014-10-17 | E-GEOD-62403 | biostudies-arrayexpress

Profiling of serum microRNAs in children with atopic dermatitis

2014-10-17 | GSE62404 | GEO

Profiling of serum microRNAs in children with atopic dermatitis

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Epigenetic and Transcriptional Dysregulation in T cells of patients with Atopic Dermatitis

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-04-26 | GSE184238 | GEO

Serum-Derived Neuronal Exosomal microRNAs as Stress-Related Biomarkers in an Atopic Dermatitis Model.

Project description:Chronic allergic inflammatory skin disease-atopic dermatitis (AD)-is characterized by eczema, pruritus, xeroderma, and lichenification. Psychological stress is one cause of this disease; however, psychological stress will also result from the presence of AD symptoms. Previous studies have shown that psychological stress triggers neuroinflammation in the brain, where microRNAs (miRNAs) in the neuronal exosomes (nEVs) were analyzed to identify the composition of the miRNAs in the nEVs and how they were altered by AD. In this study, the AD model was induced by treatment with 2,4-dinitrochlorobenzene (DNCB). The expression patterns of neuroinflammation markers, such as brain-derived neurotrophic factor, cyclooxygenase-2, and glial fibrillary acidic protein, were subsequently evaluated over time. Among these groups, there was a significant difference in DNCB 14 days expression compared with the control; therefore, nEVs were isolated from serum and next-generation sequencing was performed. The results demonstrate that 9 miRNAs were upregulated and 16 were downregulated in the DNCB 14 days compared with the control. Previous studies have shown that some of these miRNAs are associated with stress and stress-induced depression, which suggests that the miRNAs in nEVs may also be stress-related biomarkers.

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Systematic identification of genotype-dependent enhancer variants in eosinophilic esophagitis and atopic dermatitis

Project description:This SuperSeries is composed of the SubSeries listed below.

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Childhood Atopic Asthma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-11-01 | E-GEOD-65205 | biostudies-arrayexpress