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Effect of 2-aryl benzimidazole (5a) on Gene Expression Profile of the Human Breast Cancer Cells

ABSTRACT: To understand the mechanism of 2-aryl benzimidazole (5a) against breast cancer cells, we used microarray gene expression analyses to discover which target or signaling pathways were significant impact by 5a in MDA-MB-453 cells. We have investigated the mRNA expression patterns before and after 5a administration of breast cancer cells, we discovered that 5a had a significant impact on the cell cycle and MEK/Erk signaling pathways, and their p-Value were 5.62 × 10-21 and 2.04 × 10-17 respectively. We also searched for genes that exhibited the greatest differences in expression of the 5a-induced MDA-MB-453 cells relative to the control cells. Several of these genes, including FOS, JUN, TNFRSF10B (DR5), CDKN1A (p21), E2F1, E2F2 and CDC20, have been reported to relate to apoptosis and cell cycle arrest.

ORGANISM(S): Homo sapiens

PROVIDER: GSE62456 | GEO | 2015/06/01

SECONDARY ACCESSION(S): PRJNA264153

REPOSITORIES: GEO

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