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IRF4/BATF and interleukin-33 orchestrate development and maintenance of adipose tissue resident regulatory T cells

ABSTRACT: To understand the differentiation of effector Tregs in more detail, we have performed transcriptional profiling of central Tregs and effector Tregs, based on Blimp1 expression. We performed RNA-sequencing of Foxp3+ regulatory T cells, comparing Blimp1/GFP+ and Blimp1/GFP- cells

ORGANISM(S): Mus musculus

PROVIDER: GSE62535 | GEO | 2014/12/11

SECONDARY ACCESSION(S): PRJNA264362

REPOSITORIES: GEO

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IRF4/BATF and interleukin-33 orchestrate development and maintenance of adipose tissue resident regulatory T cells

Project description:To understand the differentiation of effector Tregs in more detail, we have performed transcriptional profiling of central Tregs and effector Tregs, based on Blimp1 expression. We performed RNA-sequencing of Foxp3+ regulatory T cells, comparing Blimp1/GFP+ and Blimp1/GFP- cells Three biologically independent samples for each condition were sequenced (condition 1: CD4+ CD25high Blimp1/GFP+; condition 2: CD4+ CD25high Blimp1/GFP-); cells were sorted from pooled spleens and lymphnodes of Blimp1/GFP reporter mice

2014-12-11 | E-GEOD-62535 | biostudies-arrayexpress

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