Genome-wide analysis of telomerase-regulated genes in MLL-AF9 acute myeloid leukemia stem cells (LSCs)
Ontology highlight
ABSTRACT: Genome-wide transcriptional profiling of purified telomerase deficient (Terc-/-) and WT LSCs was performed in order to gain insights into the mechanisms underlying the susceptibilities of Terc-/- LSCs in vivo. Results provide important information on the response of LSCs to telomerase deficiency, such as telomerase-dependent genes, and dysregulated cellular functions including cell cycle, DNA replication, recombination and repair, altered cellular morphology, cellular function and maintenance, and activated programmed cell death.
ORGANISM(S): Mus musculus
PROVIDER: GSE63241 | GEO | 2014/11/14
SECONDARY ACCESSION(S): PRJNA267086
REPOSITORIES: GEO
ACCESS DATA