Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

SR proteins control a complex network of RNA-processing events

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE63261 | GEO | 2014/11/23

SECONDARY ACCESSION(S): PRJNA268194

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

SR proteins control a complex network of RNA-processing events

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-11-23 | E-GEOD-63261 | biostudies-arrayexpress

SR proteins control a complex network of RNA-processing events.

Project description:SR proteins are a well-conserved class of RNA-binding proteins that are essential for regulation of splice-site selection, and have also been implicated as key regulators during other stages of RNA metabolism. For many SR proteins, the complexity of the RNA targets and specificity of RNA-binding location are poorly understood. It is also unclear if general rules governing SR protein alternative pre-mRNA splicing (AS) regulation uncovered for individual SR proteins on few model genes, apply to the activity of all SR proteins on endogenous targets. Using RNA-seq, we characterize the global AS regulation of the eight Drosophila SR protein family members. We find that a majority of AS events are regulated by multiple SR proteins, and that all SR proteins can promote exon inclusion, but also exon skipping. Most coregulated targets exhibit cooperative regulation, but some AS events are antagonistically regulated. Additionally, we found that SR protein levels can affect alternative promoter choices and polyadenylation site selection, as well as overall transcript levels. Cross-linking and immunoprecipitation coupled with high-throughput sequencing (iCLIP-seq), reveals that SR proteins bind a distinct and functionally diverse class of RNAs, which includes several classes of noncoding RNAs, uncovering possible novel functions of the SR protein family. Finally, we find that SR proteins exhibit positional RNA binding around regulated AS events. Therefore, regulation of AS by the SR proteins is the result of combinatorial regulation by multiple SR protein family members on most endogenous targets, and SR proteins have a broader role in integrating multiple layers of gene expression regulation.

| S-EPMC4274639 | biostudies-literature

SR proteins in Drosophila

Project description:This SuperSeries is composed of the SubSeries listed below.

2007-02-01 | GSE5872 | GEO

INO80 complex in the core regulatory network governing ESC self-renewal

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-05-16 | E-GEOD-49252 | biostudies-arrayexpress

ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-04-25 | E-GEOD-43192 | biostudies-arrayexpress

Transcriptome-wide mapping of RNA:protein interactions of three SR proteins in HeLa cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-31 | GSE113814 | GEO

Deciphering the Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-09-09 | E-GEOD-54901 | biostudies-arrayexpress

Protease-mediated processing of Argonaute proteins controls small RNA association

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-04-15 | GSE151717 | GEO

The PAF1 complex promotes 3‘ processing of pervasive transcripts

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-15 | GSE162843 | GEO

Cohesin and Polycomb proteins functionally interact to control transcription at silenced, restrained, and active genes

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-04-25 | E-GEOD-42106 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data