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Comparison of gene expression changes in Streptococcus pyogenes in the presence of zinc

ABSTRACT: Manuscript title: Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes. Macrophages and neutrophils release free zinc to eliminate phagocytosed bacterial pathogens. The study investigates the effect of how zinc toxicity affects Streptococcus pyogenes. Therefore, a microarray analysis was performed in S. pyogenes cells to determine gene expression changes when exposed to high levels of zinc. We discovered that a pathway involved in tagatose-6-phosphate metabolism was upregulated when the cells are under zinc stress.

ORGANISM(S): Streptococcus pyogenes

PROVIDER: GSE63436 | GEO | 2015/11/30

SECONDARY ACCESSION(S): PRJNA267730

REPOSITORIES: GEO

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