Transcriptomics

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Gene expression analysis of Stabilin-1 positive human monocytes


ABSTRACT: Stabilin-1/CLEVER-1 is a multidomain protein present in lymphatic and vascular endothelial cells and in M2 immunosuppressive macrophages. Stabilin-1 functions in scavenging, endocytosis and leukocyte adhesion to and transmigration through the endothelial cells. We analyzed the putative functions of Stabilin-1 in blood monocytes. We found that in healthy individuals 60-80% of both CD14+CD16- and CD14+C16+ monocytes, but not CD14dimCD16+ monocytes, expressed Stabilin-1 on the surface. Microarray analysis was performed to study these monocytes subtypes in more detail.

ORGANISM(S): Homo sapiens

PROVIDER: GSE63519 | GEO | 2015/11/30

SECONDARY ACCESSION(S): PRJNA268108

REPOSITORIES: GEO

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