Transcriptomics

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Gene-profile comparison of wt and Ifnb–/– cerebellar granular neurons


ABSTRACT: Interferon-b (IFN-b) belongs to the type I interferon family of cytokines and via binding to its receptor, interferon-a/b-receptor (IFNAR), it exerts immunoregulatory effects such as anti-viral and anti-inflammatory properties, and clinical benefits for patients with the CNS disease multiple sclerosis. To compare differentially regulated genes in neurons of interferon-beta knock out mice (Ifnb–/–), we conducted a microarray analysis on cerebellar granular neurons (CGNs) from wt (Ifnb+/+) and Ifnb-/- mice with or without treatment with recombinant IFN-b.

ORGANISM(S): Mus musculus

PROVIDER: GSE63815 | GEO | 2015/10/08

SECONDARY ACCESSION(S): PRJNA269143

REPOSITORIES: GEO

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