Transcriptomics

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Profiling of bacterial respiratory infection, viral respiratory infection, and non-infectious illness


ABSTRACT: A pressing clinical challenge is identifying the etiologic basis of acute respiratory illness. Without reliable diagnostics, the uncertainty associated with this clinical entity leads to a significant, inappropriate use of antibacterials. Use of host peripheral blood gene expression data to classify individuals with bacterial infection, viral infection, or non-infection represents a complementary diagnostic approach. Patients with respiratory tract infection along with ill, non-infected controls were enrolled through the emergency department or undergraduate student health services. Whole blood was obtained to generate gene expression profiles. These profiles were then used to generate signatures of bacterial acute respiratory infection, viral acute respiratory infection, and non-infectious illness.

ORGANISM(S): Homo sapiens

PROVIDER: GSE63990 | GEO | 2016/01/20

SECONDARY ACCESSION(S): PRJNA269949

REPOSITORIES: GEO

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