Genomics

Dataset Information

0

MYC-negative BL frequent in posttransplant patients (cytogenetic)


ABSTRACT: We performed genomic and transcriptomic analysis of seven cases of molecular Burkitt lymphoma (mBL) developed in immunosuppressed patients who underwent solid organ transplantation. Interestingly, three cases (43%) were MYC-translocation-negative and revealed the 11q-gain/loss aberration recently identified in 3% of mBL developed in immunocompetent hosts.1 Based on array CGH data, minimal gain and loss regions of 11q (MGR/~4Mb and MLR/~13.5Mb, respectively) were defined and integrative genomic and transcriptomic analysis identified 35 differentially expressed genes, when compared with classic BL. All 16 MGR-dysregulated genes were upregulated, including cancer related USP2, CBL and PAFAH1B2. As expected, all 19 MGL-dysregulated genes were downregulated and two of them, TBRG1 and EI24, are potential tumor suppressor genes. Interestingly, the vast majority of dysregulated 11q23-q25 genes are involved in the MYC and TP53 networks. We hypothesize that the 11q-gain/loss aberration represents a “molecular variant” of t(8q24/MYC) and affects the same pathological pathways as the MYC oncogene.

ORGANISM(S): Homo sapiens

PROVIDER: GSE64083 | GEO | 2014/12/12

SECONDARY ACCESSION(S): PRJNA270080

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-12-12 | GSE64085 | GEO
2014-12-12 | E-GEOD-64083 | biostudies-arrayexpress
2014-12-12 | E-GEOD-64085 | biostudies-arrayexpress
2019-07-30 | GSE93002 | GEO
| PRJNA384953 | ENA
2019-02-19 | GSE116526 | GEO
2019-02-19 | GSE116522 | GEO
2019-02-19 | GSE116518 | GEO
2012-09-04 | GSE31892 | GEO
2013-12-31 | GSE44164 | GEO