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Expression profile from murine acute myeloid leukemia cells C1498 with or without PARP-1 inhibition

ABSTRACT: Poly(ADP-ribose) polymerase 1 (PARP-1) is abnormally expressed in a wide variety of tumors. Emerging evidence suggests that PARP-1 plays key roles in multiple biologic behaviors of tumors, such as modulation of chromatin structure, regulation of gene transcription, tumor proliferation, apoptosis, and angiogenesis, by acting on different molecular pathways. PARP-1 inhibition can achieve a beneficial outcome in tumor treatment. But the specific mechanism of PARP-1 in acute myeloid leukemia (AML) is still to be discovered. We used microarrays to detail the global gene expression in C1498 with and without PARP-1 inhibition and profile differentially expressed genes that might be involved in PARP-1 regulation in AML.

ORGANISM(S): Mus musculus

PROVIDER: GSE64220 | GEO | 2016/08/31

SECONDARY ACCESSION(S): PRJNA270404

REPOSITORIES: GEO

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