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Expression comparison of mutant EGFR-driven gliomas with relapse tumors upon mutant EGFR ablation

ABSTRACT: To determine the roles of oncogenic EGFR signaling in gliomagenesis and tumor maintenance, we generated a novel glioma mouse model driven by inducible expression of a mutant EGFR (EGFR*). Genetic suppression of EGFR* induction led to significant tumor regression and prolonged survival. But in spite of the initial response, the tumors relapsed invariably and propagated independent of EGFR*. We used microarrys to directly compare geen expression of control and relapse tumors and identified gene sets specifically activated in relapse tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE64751 | GEO | 2015/01/08

SECONDARY ACCESSION(S): PRJNA271792

REPOSITORIES: GEO

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Expression comparison of mutant EGFR-driven gliomas with relapse tumors upon mutant EGFR ablation

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