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Gene expression and methylation profile for male SD Rats upon fructose and DHA treatment

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE64817 | GEO | 2016/07/15

SECONDARY ACCESSION(S): PRJNA271941

REPOSITORIES: GEO

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Similar Datasets

Gene expression and methylation profile for male SD Rats upon fructose and DHA treatment

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-07-15 | E-GEOD-64817 | biostudies-arrayexpress

DNA methylation profile for male SD Rats upon fructose and DHA treatment by RRBS

Project description:To investigate the beneficial effects of DHA (omega-3) on affecting fructose induced brain dysfunction and metabolic disorders by sequencing the methylome (RRBS) in the hypothalamus and hippocampus of male SD rats.

2016-10-19 | GSE64816 | GEO

Gene expression profile for male SD Rats upon fructose and DHA treatment by RNA-Seq

Project description:To investigate the beneficial effects of DHA (omega-3) on affecting fructose induced brain dysfunction and metabolic disorders by sequencing the transcripome (RNA-Seq) in the hypothalamus and hippocampus of male SD rats.

2016-07-13 | GSE64815 | GEO

DNA methylation profile for male SD Rats upon fructose treatment by RRBS

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Gene expression profile for male SD Rats upon fructose treatment by RNA-Seq

Project description:Gene expression profile for male SD Rats upon fructose treatment by RNA-Seq

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Gene expression and DNA methylation profiles for male SD Rats with and without traumatic brain injury

Project description:This SuperSeries is composed of the SubSeries listed below.

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DNA methylation profile for male SD rats with and without traumatic brain injury (TBI) by RRBS

Project description:To investigate the effects of TBI on affecting the DNA methylation in the hippocampus of male SD rats by sequencing the methylome (RRBS).

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DNA Methylation profile for male SD Rats with and without traumatic brain injury (TBI) by RRBS-Seq

Project description:To investigate the effects of TBI on affecting DNA methylations in the WBC of male SD rats by RRBS.

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DNA Methylation profile for male SD Rats with and without traumatic brain injury (TBI) by RNA-Seq, batch2

Project description:To investigate the effects of TBI on affecting DNA methylations in the WBC of male SD rats by RRBS.

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Transcription profiling of liver, pancreas and lung tissue of male SD rats and CRISPR/Cas-9-mediated knockout SD-Nme7-/- male rats

Project description:We aimed to compare the transcriptome of liver, pancreas, and lung tissue of adult male SD rats and the novel CRISPR/Cas-9-mediated knockout SD-Nme7-/- adult male rats using Affymetrix Rat Gene 2.1 ST Array Strip. Total RNA was isolated from the liver, pancreas, and lung tissues (RNeasy Mini Kit, Qiagen) of SD and SDNme7-/- rats. The quality and integrity of the total RNA was evaluated on the Agilent 2100 Bioanalyzer system (Agilent, Palo Alto, CA). Microarray experiments were performed using the Rat Gene 2.1 ST Array Strip. The whole hybridization procedure was performed using the Affymetrix GeneAtlas® system according to the manufacturer's instructions. The quality control of the chips was performed using Affymetrix Expression Console. After applying quality filters and data normalization by the Robust Multichip Average (RMA) algorithm implemented in Affymetrix Expression Console, the set of obtained differentially expressed probesets was filtered by the false discovery rate (FDR) method implemented in PARTEK Genomics Suite 7 (Partek, St. Louis, Missouri). Transcriptomic data were then processed by a standardized sequence of analyses (hierarchical clustering and principal component analysis, gene ontology, gene set enrichment, Upstream Regulator Analysis, Mechanistic Networks, Causal Network Analysis, and Downstream Effects Analysis) using Ingenuity Pathway Analysis.

2021-04-06 | E-MTAB-10000 | biostudies-arrayexpress

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