Transcriptomics

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Hepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet


ABSTRACT: Xbp1 is an important regulator of unfolded protein response and lipid metabolism. Its dyregulation has been associcated in human NASH. Feeding a high fat diet with fructose/sucrose to mice causes progressive, fibrosing steatohepatitis. This study is to use RNA-Seq to identify differentially expressed genes in hepatic Xbp1 deficient mice livers fed with a high fat diet compared to controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE64824 | GEO | 2016/01/07

SECONDARY ACCESSION(S): PRJNA271953

REPOSITORIES: GEO

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