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Functional heterogeneity of human memory T cell clones primed by pathogens or vaccines

ABSTRACT: It is unclear to what extent T helper cells with a different phenotype (chemokine receptor and cytokine production profile) are generated in response to pathogen challenge or vaccination, and whether such heterogeneity can arise among the progeny of a single precursor. We combined cellular methods to isolate antigen specific T cells from different T helper memory subsets of human donors, and next generation sequencing of their TCR. This approach revealed a high level of heterogeneity in the phenotype of human T cells responding to different pathogens/vaccines also at a clonal level, as we could characterize cells bearing an identical T cell receptor with divergent effector properties.

ORGANISM(S): Homo sapiens

PROVIDER: GSE64852 | GEO | 2015/01/13

SECONDARY ACCESSION(S): PRJNA272412

REPOSITORIES: GEO

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Functional heterogeneity of human memory T cell clones primed by pathogens or vaccines

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