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Transcriptomic analysis of colonic epithelial cells in adult rats born with intra-uterine growth retardation.

ABSTRACT: The impact of intra-uterine growth retardation (IUGR) was analyzed on gene expression of the colonic epithelial cells from adults rats fed a standard or a high-fat diet. The hypothesis tested in this study was that IUGR induces sustainable effects on colonocyte transcriptome that may alter further nutritional adaptations at adulthood, especially to high-fat diet.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE65051 | GEO | 2015/11/01

SECONDARY ACCESSION(S): PRJNA272799

REPOSITORIES: GEO

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Transcriptomic analysis of colonic epithelial cells in adult rats born with intra-uterine growth retardation.

Project description:The impact of intra-uterine growth retardation (IUGR) was analyzed on gene expression of the colonic epithelial cells from adults rats fed a standard or a high-fat diet. The hypothesis tested in this study was that IUGR induces sustainable effects on colonocyte transcriptome that may alter further nutritional adaptations at adulthood, especially to high-fat diet. Total RNA extracted from control (C) and IUGR (R) rats fed chow (Normal Diet, ND) or high-fat diet (HFD).

2015-11-01 | E-GEOD-65051 | biostudies-arrayexpress

Transcription profiling of rat heart, kidney and placenta from fetuses obtained from dams with diet-induced intra-uterine growth restriction vs. normal

Project description:Pregnant rats were randomly divided into two groups. Dams were then housed individually and fed throughout gestation a 22 % protein diet, representing the control group (C, n=5), or an 9% isocaloric protein diet, representing the low-protein (LP, n=6). Both diets were isocaloric, because the protein deficiency in the LP diet was compensated by the addition of carbohydrates. Feeding of LP diet began on the day of conception and continuing throughout pregnancy. The low-protien diet resulted in Intra-Uterine Growth Restriction (IUGR) of the fetuses.<br><br> An additional processed data file, E-MEXP-1015_all_norm_calls.txt, is available for download from <a href="ftp://ftp.ebi.ac.uk/pub/databases/microarray/data/experiment/MEXP/E-MEXP-1015/">ftp://ftp.ebi.ac.uk/pub/databases/microarray/data/experiment/MEXP/E-MEXP-1015/</a>

2007-11-03 | E-MEXP-1015 | biostudies-arrayexpress

CpG Island methylation variation in placentae of Intra-Uterine Growth Restricted (IUGR) fetuses versus controls

Project description:Methylation profiling of CpG Island Methylation of genomic DNA samples extracted from placentae of Intra-Uterine Growth Restricted newborns and gestational age matched controls. These data can be used for methylation comparisons between these two types of samples. The results of such comparisons can be used to generate hypotheses on the involvement of DNA methylation variation in placenta development and fetal growth. Two-condition Methyl DNA Immunoprecipitation (MeDIP) experiment, IUGR vs. Control placenta samples. Biological replicates: 8 control, 8 IUGR cases.

2011-04-11 | E-GEOD-22326 | biostudies-arrayexpress

Effects of dietary fat on neurodevelopmental outcomes in normal birth weight and intrauterine growth restricted piglets

Project description:Breast milk has shown neurodevelopmental advantages compared to infant formula, especially in IUGR infants, which may relate to the fat source. This study aimed to compare neurodevelopmental outcomes in normal birth weight (NBW) and intrauterine growth restricted (IUGR) piglets fed a formula diet with either a vegetable oil (VEG) or bovine milk fat source (MILK). Results showed that total plasma lipids were increased by feeding the MILK diet. 82% and 11% of lipid species were differentially expressed between dietary groups in plasma and hippocampus, respectively, with slight agreement between the plasma and brain lipidome. The MILK diet was most effective in increasing brain lipid accretion, mainly comprising phospholipids. Absolute regional brain weights, grey and white matter volumes, and behavior and motor function scores were lower in IUGR piglets with no effects of diet. Cognitive function and gene expression profiles were similar for dietary and weight groups, and overall only minor interactive effects between diet and weight were observed. In conclusion, dietary fat source influenced the plasma and to a lesser degree the hippocampal lipidome, but was unable to improve on IUGR induced brain structural and functional impairments.

2022-02-16 | GSE182263 | GEO

Mental Retardation Patients

Project description:Profiling the genomic profiles of mental retardation patients. 13 mental retardation patients were selected for detection of genomic aberrations.

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Mental Retardation Patients

Project description:Profiling the genomic profiles of mental retardation patients. 13 mental retardation patients were selected for detection of genomic aberrations. Patient's DNA were hybridized against Promega control on Agilent G4426B arrays and scanned with the Agilent G2505B scanner.

2010-05-18 | E-GEOD-19457 | biostudies-arrayexpress

Membrane proteomic analysis reveals the intestinal development is deteriorated by intra-uterine growth restriction in piglets

Project description:The alterations of the intestinal proteome was observed in intrauterine growth restriction (IUGR) piglets during early life by gel-based approaches. Nevertheless, how IUGR affects the intestinal membrane proteome during neonatal development remains unclear. Here, we applied the iTRAQ-based proteomics technology and biochemical analysis to investigate the impact of IUGR on the membrane proteome of the jejunal mucosa in the piglets. 361 membrane proteins were screened by functional prediction. Among them, eight, five and one differentially expressed membrane proteins were identified between IUGR and NBW piglets at day 0, day 7 and day 21 after birth, respectively. Differentially expressed membrane proteins (DEMPs) including F1SBL3, F1RRW8, F1S539, F1S2Z2, F1RIR2, F1RUF2 I3LP60, Q2EN79 and F1SIH8 were reduced while the relative abundance of I3L6A2, F1SCJ1, F1RI18, I3LRJ7 and F1RNN0 were increased in IUGR piglets than NBW piglets. From the aspects of function, F1RRW8, F1S539, F1S2Z2 and F1RIR2 are mainly associated with D2 dopamine receptor binding, transmembrane transport of small molecules, signal transduction and translocation of GLUT4, respectively, and F1SIH8, I3LRJ7 and F1RNN0 are related to autophagy, metabolism of vitamins and intracellular protein transport. Additionally, IUGR decreased the level of proteins (F1RRW8, Q2EN79 and F1RI18) that are involved in response to oxidative stress.

2019-03-29 | PXD013315 |

Placental multi-omics data-mining in Intra-Uterine Growth Restriction

Project description:Methylomics and transcriptomics array-based analysis of 36 placentas: 28 with IUGR (Intra-Uterine Growth Restriction) vs. 8 control pregnancies. Methylomics data were obtained using Illumina HumanMethylation-450k microarrays. Transcriptomics data were obtained using Illumina HumanHT-12 v4 Expression BeadChips.

| EGAS00001003467 | EGA

Gene expression in adipose tissue of intrauterine growth restricted (IUGR) and Macrosomic animals that developed in a crowded uterine horn

Project description:Animals that are growth restricted in utero may show rapid postnatal growth that ultimately results in adult obesity. Macrosomic animals at birth typically remain large and are also obese as adults. Our goal was to examine the differences between animals that reach obesity in different ways. We also aimed to examine gene expression in animals that start out lean and stay lean compared to those that start out lean and become fat. We used microarrays to detail gene expression in adipose tissue. 3 samples each from IUGR animals with rapid postnatal growth (IH), IUGR animals with slower postnatal growth (IL), and macromsomic animals (M).

2012-04-24 | E-GEOD-33761 | biostudies-arrayexpress

Variation of the Intestinal Microbiome during the life course of the Intra-Uterine Growth Restricted Rat Offspring Exposed to a High Fat and Fructose Diet

Project description:We reported the variation in the gut microbiome diversity under the influence of Intrauterine Growth restriction or Exposure to High Fat High fructose diet followed by Intrauterine growth restriction.

2023-01-11 | GSE220146 | GEO

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